Two years has passed since the vampires blocked out the sun. Humans live in blood farms where the vampires milk them and only small groups of survivors continue to resist the vampire occupation. The people from the previous books now try to decipher the Occido Lumen, a book which may hold the key to defeat the vampires.

The vampire now try to start to take over the whole world. Wealthy people are lured with promise of immortality as they start to kill anyone that could resist them. The heroes try to fight back as well as they can and it looks like they found an ally in some vampires that do not approve of the war.

A plane lands at an airport in New York but when the ground crew looks inside everyone on it is found dead. Soon the people who are investigating biological threats learn that the plane contained a vampiric virus and it is spreading fast. The team up with a survivor of the Holocaust who has been waiting for this. The vampires war on the humans is about to start.